This reference design uses nano-power operational amplifiers: comparators: system timers: temperature sensors and the SimpleLink™ ultra-low power 2.4-GHz wireless microcontroller (MCU) platform to demonstrate an ultra-low power carbon-monoxide detector implementation. These technologies lead to an extremely long battery life of over 10 years with a standard CR2032 lithium-ion coin-cell battery: which could be used for applications including gas detection or air quality monitoring. The carbon monoxide detector has sensitivity up to 1000 ppm with a standby current of 1.07 µA. The design guide includes techniques for system design: detailed test results and information to get the design up and running quickly.