This reference design enables a cost-effective and low-power data acquisition system that provides an alternative to FPGA-based systems. It features a single-ended: high-impedance input that can be used in a wide number of applications: including portable instrumentation and digitizers.The reference design utilizes the ADS4122 analog-to-digital converter (ADC): along the with the OPA656 and THS4541 operational amplifiers (op amps) to develop a 12-bit: 20-MSPS digitizer for the BeagleBone Cape form factor. The expansion board devleoped in this reference design interfaces with the BeagleBone Black development platform: which is a low-cost: open-source: community-supported environment based on the ARM Cortex-A8 processor.