This reference design implements an RF mesh network end node with DTLS security for smart meter Advanced Metering Infrastructure (AMI) networks. The network is an IPv6 over low-power wireless personal area networks (6LoWPAN) solution. The design implements this network in a single CC1312R SimpleLink™ Wireless MCU to enhanceperformance and minimize system cost. The complete 6LoWPAN mesh network runs on top of the TI-15.4 stack based on IEEE 802.15.4e/g protocols and implements an un-slotted channel hopping (USCH) mode to provide protection against network interference. Network capacity is improved and the security is enhanced compared to TIDA-010003 end node design with the inclusion of larger neighbor and routing tables that optimize packet routing decisions.