This reference design provides a protected: efficient (headroom-controlled): high-current (up to 1.5 A): linear (accurate and fast) light-emitting diode (LED) driver reference design to enable peripheral capillary oxygen saturation (SpO2) and other medical applications. A typical SpO2 application drives current through LEDs. Most of these drivers are integrated with analog front-end devices and work at the typical value of 100 mA. A higher current drive is necessitated to cover wide range of human and veterinary physiology. This design enables self-calibration and uses a look-up table for headroom control to optimally drive LEDs resulting in minimum power dissipation across the control element. The design operated from an input voltage range of 1.8 V to 4.2V and enables LED currents up to 1.5 A.