This reference design is a continuous wave (CW) signal conditioning for ultrasound imaging systems (64-: 128-: 192-: 256-channel ultrasound system). This design features 20-bit fully differential simultaneous sampling with true raw data available for processing. It consists of a fully-differential signal path for I and Q channels: each using high-performance SAR analog-to-digital converter (ADCs) (ADS8900B): fully-differential precision amplifier (THS4551): a dual low-noise: low dropout (LDO) voltage regulator (TPS7A8801) and a precision voltage reference (REF5050). TIDA-01351 can be interfaced with the PH1-EVM controller through the multiSPI™ digital interface: and the performance can be evaluated using a PC-based graphical user interface (GUI) from any PC through the USB interface.